Association of Early-Life Cognitive Enrichment With Alzheimer Disease Pathological Changes and Cognitive Decline.

ABSTRACT:

Importance

Indicators of early-life cognitive enrichment (ELCE) have been associated with slower cognitive decline and decreased dementia in late life. However, the mechanisms underlying this association have not been elucidated.

Objective

To examine the association of ELCE with late-life Alzheimer disease (AD) and other common dementia-related pathological changes.

Design, setting, and participants

This clinical-pathological community-based cohort study, the Rush Memory and Aging Project, followed up participants before death for a mean (SD) of 7.0 (3.8) years with annual cognitive and clinical assessments. From January 1, 1997, through June 30, 2019, 2044 participants enrolled, of whom 1018 died. Postmortem data were leveraged from 813 participants. Data were analyz

SUBMITTER: Oveisgharan S 

PROVIDER: S-EPMC7325069 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature