Mitch: multi-contrast pathway enrichment for multi-omics and single-cell profiling data.

ABSTRACT:

Background

Inference of biological pathway activity via gene set enrichment analysis is frequently used in the interpretation of clinical and other omics data. With the proliferation of new omics profiling approaches and ever-growing size of data sets generated, there is a lack of tools available to perform and visualise gene set enrichments in analyses involving multiple contrasts.

Results

To address this, we developed mitch, an R package for multi-contrast gene set enrichment analysis. It uses a rank-MANOVA statistical approach to identify sets of genes that exhibit joint enrichment across multiple contrasts. Its unique visualisation features enable the exploration of enrichments in up to 20 contrasts. We demonstrate the utility of mitch with case studies spanning multi-co

SUBMITTER: Kaspi A 

PROVIDER: S-EPMC7325150 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature