Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.

ABSTRACT: The loss of vital cells within healthy tissues contributes to the development, progression and treatment outcomes of many human disorders, including neurological and infectious diseases as well as environmental and medical toxicities. Conversely, the abnormal survival and accumulation of damaged or superfluous cells drive prominent human pathologies such as cancers and autoimmune diseases. Apoptosis is an evolutionarily conserved cell death pathway that is responsible for the programmed culling of cells during normal eukaryotic development and maintenance of organismal homeostasis. This pathway is controlled by the BCL-2 family of proteins, which contains both pro-apoptotic and pro-survival members that balance the decision between cellular life and death. Recent insights into the dynamic

SUBMITTER: Singh R 

PROVIDER: S-EPMC7325303 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature