Ontology highlight
ABSTRACT:
SUBMITTER: Gibiansky L
PROVIDER: S-EPMC7325316 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Gibiansky Leonid L Ravva Patanjali P Parrott Neil J NJ Bhardwaj Rajinder R Zwanziger Elke E Grimsey Paul P Clinch Barry B Sturm Stefan S
Clinical pharmacology and therapeutics 20200226 1
A mechanistic population-pharmacokinetic model was developed to predict oseltamivir exposures in neonates and infants accounting for physiological changes during the first 2 years of life. The model included data from 13 studies, comprising 436 subjects with normal renal function (317 pediatric subjects (≥ 38 weeks postmenstrual age (PMA), ≥ 13 days old) and 119 adult subjects < 40 years). Concentration-time profiles of oseltamivir and its active metabolite, oseltamivir carboxylate (OC), were ch ...[more]