Novel 3D embryo implantation model within macroporous alginate scaffolds.

ABSTRACT:

Background

Implantation failure remains an unsolved obstacle in reproductive medicine. Previous studies have indicated that estrogen responsiveness, specifically by estrogen receptor alpha (ERα), is crucial for proper implantation. There is an utmost need for a reliable in vitro model that mimics the events in the uterine wall during the implantation process for studying the regulatory mechanisms governing the process. The current two-dimensional and hydrogel-based in vitro models provide only short-term endometrial cell culture with partial functionality.

Results

Endometrial biopsies showed an increase in E-cadherin expression on the typical window of implantation of fertile women, compared to negligible expression in recurrent implantation failure (RIF) patients. These cli

SUBMITTER: Stern-Tal D 

PROVIDER: S-EPMC7325373 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature