Mitochondrial Dysfunction is Associated With an Immune Paralysis Phenotype in Pediatric Sepsis.

ABSTRACT:

Objective

Immune dysregulation is a defining feature of sepsis, but the role for mitochondria in the development of immunoparalysis in pediatric sepsis is not known. We sought to determine if mitochondrial dysfunction measured in peripheral blood mononuclear cells (PBMCs) is associated with immunoparalysis and systemic inflammation in children with sepsis.

Design

Prospective observational study.

Setting

Single-academic pediatric intensive care unit (PICU).

Patients

One hundred sixty-one children with sepsis/septic shock and 18 noninfected PICU controls.

Measurements and main results

Mitochondrial respiration in PBMCs, markers of immune function, and plasma cytokines were measured on days 1 to 2 (T1), 3 to 5 (T2), and 8 to 14 (T3) after sepsis recognition

SUBMITTER: Weiss SL 

PROVIDER: S-EPMC7325426 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature