NF-κB signaling regulates the formation of proliferating Muller glia-derived progenitor cells in the avian retina.

ABSTRACT: Retinal regeneration is robust in some cold-blooded vertebrates, but this process is ineffective in warm-blooded vertebrates. Understanding the mechanisms that suppress the reprogramming of Müller glia into neurogenic progenitors is key to harnessing the regenerative potential of the retina. Inflammation and reactive microglia are known to influence the formation of Müller glia-derived progenitor cells (MGPCs), but the mechanisms underlying this interaction are unknown. We used a chick in vivo model to investigate nuclear factor kappa B (NF-κB) signaling, a critical regulator of inflammation, during the reprogramming of Müller glia into proliferating progenitors. We find that components of the NF-κB pathway are dynamically regulated by Müller glia after neuronal damage or tre

SUBMITTER: Palazzo I 

PROVIDER: S-EPMC7325431 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature