A Role for PGC-1α in Transcription and Excitability of Neocortical and Hippocampal Excitatory Neurons.

ABSTRACT: The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a critical regulator of genes involved in neuronal metabolism, neurotransmission, and morphology. Reduced PGC-1α expression has been implicated in several neurological and psychiatric disorders. An understanding of PGC-1α's roles in different cell types will help determine the functional consequences of PGC-1α dysfunction and/or deficiency in disease. Reports from our laboratory and others suggest a critical role for PGC-1α in inhibitory neurons with high metabolic demand such as fast-spiking interneurons. Here, we document a previously unrecognized role for PGC-1α in maintenance of gene expression programs for synchronous neurotransmitter release, structure, and metabolism in neocortica

SUBMITTER: McMeekin LJ 

PROVIDER: S-EPMC7325608 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature