Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes.

ABSTRACT:

Purpose

The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus show different responses to intraocular pressure (IOP) elevation.

Methods

Anesthetized adult Long Evans rats (n = 14) were imaged using optical coherence tomography angiography (OCTA; Spectralis) at baseline (IOP 10 mm Hg) and in follow-up mode to examine the vasculature during IOP elevation (10 to 110 mm Hg, 10 mm Hg steps, each step 3 minutes). A 20° × 10° field was imaged. Vessel density within a 2D projection image was determined (%) for the superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Comparisons were made between layers using 2-way repeated measures ANOVA (layer versus IOP) followi

SUBMITTER: Zhao D 

PROVIDER: S-EPMC7325622 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature