The evolution of the Puf superfamily of proteins across the tree of eukaryotes.

ABSTRACT:

Background

Eukaryotic gene expression is controlled by a number of RNA-binding proteins (RBP), such as the proteins from the Puf (Pumilio and FBF) superfamily (PufSF). These proteins bind to RNA via multiple Puf repeat domains, each of which specifically recognizes a single RNA base. Recently, three diversified PufSF proteins have been described in model organisms, each of which is responsible for the maturation of ribosomal RNA or the translational regulation of mRNAs; however, less is known about the role of these proteins across eukaryotic diversity.

Results

Here, we investigated the distribution and function of PufSF RBPs in the tree of eukaryotes. We determined that the following PufSF proteins are universally conserved across eukaryotes and can be broadly classified in

SUBMITTER: Najdrova V 

PROVIDER: S-EPMC7325665 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature