Identification of Prognostic Biomarkers for Multiple Solid Tumors Using a Human Villi Development Model.

ABSTRACT: The processes of embryonic development that rely on epithelial-mesenchymal transition (EMT) for the implantation of trophoblast cells are co-opted by tumors, reflecting their inherent uncontrolled characteristics and leading to invasion and metastasis. Although tumorigenesis and embryogenesis have similar EMT characteristics, trophoblasts have been shown to exhibit "physiological metastasis" or be "pseudo-malignant," resulting in different outcomes. The gene co-expression network is the basis of embryonic development and tumorigenesis. We hypothesize that if the gene co-expression network in tumors is "off-track" from that in villi, it is more likely to develop into malignant tumors and have a worse prognosis, and we proposed the "off-track theory" for the first time. In this study, we exa

SUBMITTER: Zhang B 

PROVIDER: S-EPMC7325693 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature