Effects of Intensive Blood Pressure Lowering on Kidney Tubule Injury in CKD: A Longitudinal Subgroup Analysis in SPRINT.

ABSTRACT:

Background

Random assignment to the intensive systolic blood pressure (SBP) arm (<120mmHg) in the Systolic Blood Pressure Intervention Trial (SPRINT) resulted in more rapid declines in estimated glomerular filtration rates (eGFRs) than in the standard arm (SBP<140mmHg). Whether this change reflects hemodynamic effects or accelerated intrinsic kidney damage is unknown.

Study design

Longitudinal subgroup analysis of clinical trial participants.

Settings & participants

Random sample of SPRINT participants with prevalent chronic kidney disease (CKD) defined as eGFR<60mL/min/1.73m² by the CKD-EPI (CKD Epidemiology Collaboration) creatinine-cystatin C equation at baseline.

Outcomes & measurements

Urine biomarkers of tubule function (β₂-microglob

SUBMITTER: Malhotra R 

PROVIDER: S-EPMC7325694 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature