Generation of a glycosylated asparagine residue through chemoselective acylation of a glycosylhydrazide.
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ABSTRACT:
SUBMITTER: Rykaczewski KA
PROVIDER: S-EPMC7325706 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Generation of a glycosylated asparagine residue through chemoselective acylation of a glycosylhydrazide.
Rykaczewski Katie A KA Sabourin Kate E KE Goo Paul J PJ Griggs Lydia H LH Jain Saumya S Reed Paxton A M PAM Langenhan Joseph M JM
Carbohydrate research 20200504
Herein, we report the first selective anomeric N-acylation of a glycosylhydrazide. We show that this transformation can be harnessed to generate amino acid building blocks including FmocAsn(GlcNAc)OH (1), a residue that has been previously shown to be a competent reagent in the solid-phase peptide synthesis of N-linked glycopeptides. ...[more]
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