Spatiotemporal Differences in the Regional Cortical Plate and Subplate Volume Growth during Fetal Development.

ABSTRACT: The regional specification of the cerebral cortex can be described by protomap and protocortex hypotheses. The protomap hypothesis suggests that the regional destiny of cortical neurons and the relative size of the cortical area are genetically determined early during embryonic development. The protocortex hypothesis suggests that the regional growth rate is predominantly shaped by external influences. In order to determine regional volumes of cortical compartments (cortical plate (CP) or subplate (SP)) and estimate their growth rates, we acquired T2-weighted in utero MRIs of 40 healthy fetuses and grouped them into early (<25.5 GW), mid- (25.5-31.6 GW), and late (>31.6 GW) prenatal periods. MRIs were segmented into CP and SP and further parcellated into 22 gyral regions. No significant di

SUBMITTER: Vasung L 

PROVIDER: S-EPMC7325717 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature