Reward Timing and Its Expression by Inhibitory Interneurons in the Mouse Primary Visual Cortex.

ABSTRACT: The primary sensory cortex has historically been studied as a low-level feature detector, but has more recently been implicated in many higher-level cognitive functions. For instance, after an animal learns that a light predicts water at a fixed delay, neurons in the primary visual cortex (V1) can produce "reward timing activity" (i.e., spike modulation of various forms that relate the interval between the visual stimulus and expected reward). Local manipulations to V1 implicate it as a site of learning reward timing activity (as opposed to simply reporting timing information from another region via feedback input). However, the manner by which V1 then produces these representations is unknown. Here, we combine behavior, in vivo electrophysiology, and optogenetics to investigate the charac

SUBMITTER: Monk KJ 

PROVIDER: S-EPMC7325719 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature