Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice.

ABSTRACT:

Background

Tuberculosis (TB) treatment is lengthy and complicated and patients often develop chronic lung disease. Recent attention has focused on host-directed therapies aimed at optimizing immune responses to Mycobacterium tuberculosis (Mtb), as adjunctive treatment given with antitubercular drugs. In addition to their cholesterol-lowering properties, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have broad anti-inflammatory and immunomodulatory activities.

Methods

In the current study, we screened 8 commercially available statins for cytotoxic effect, anti-TB activity, synergy with first-line drugs in macrophages, pharmacokinetics and adjunctive bactericidal activity, and, in 2 different mouse models, as adjunctive therapy to first-line TB drugs.

SUBMITTER: Dutta NK 

PROVIDER: S-EPMC7325721 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature