Blood amyloid levels and risk of dementia in the Ginkgo Evaluation of Memory Study (GEMS): A longitudinal analysis.

ABSTRACT:

Introduction

Both high or low plasma amyloid levels have been associated with risk of dementia in nondemented subjects.

Methods

We examined baseline plasma β-amyloid (Aβ) levels in relationship to incident dementia during a period of 8.5 years in 2840 subjects age >75 years; 2381 were cognitively normal (CN) and 450 mild cognitive impairment.

Results

Increased plasma Aβ1-40 and Aβ1-42 levels were associated with gender (women), age, low education, creatinine levels, history of stroke, and hypertension. CN participants who developed dementia had lower levels of Aβ1-42 and Aβ1-42/Aβ1-40 ratio compared with those who did not. Aβ levels did not predict dementia in mild cognitive impairment participants.

Discussion

There was an inverse association between Aβ1-42 and

SUBMITTER: Lopez OL 

PROVIDER: S-EPMC7325728 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature