Evaluation of risk factors for pseudo-obstruction in systemic sclerosis.

ABSTRACT:

Objective

Although up to 90% of systemic sclerosis (SSc) patients are affected by gastrointestinal (GI) dysmotility, the clinical phenotype of patients with pseudo-obstruction is not well-defined. We sought to identify this phenotype by studying a large cohort of SSc patients with and without pseudo-obstruction.

Methods

We performed a retrospective analysis of patients seen at the Johns Hopkins Scleroderma Center between February 2003 and September 2017. All SSc patients had clinical data prospectively collected in a longitudinal database. Cross-sectional analyses were performed comparing autoantibody status and clinical and demographic features of patients with and without pseudo-obstruction. Cox proportional hazards regression was used to identify risk factors for pseudo-o

SUBMITTER: Dein E 

PROVIDER: S-EPMC7325733 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature