Compositional Lotka-Volterra describes microbial dynamics in the simplex.

ABSTRACT: Dynamic changes in microbial communities play an important role in human health and disease. Specifically, deciphering how microbial species in a community interact with each other and their environment can elucidate mechanisms of disease, a problem typically investigated using tools from community ecology. Yet, such methods require measurements of absolute densities, whereas typical datasets only provide estimates of relative abundances. Here, we systematically investigate models of microbial dynamics in the simplex of relative abundances. We derive a new nonlinear dynamical system for microbial dynamics, termed "compositional" Lotka-Volterra (cLV), unifying approaches using generalized Lotka-Volterra (gLV) equations from community ecology and compositional data analysis. On three real da

SUBMITTER: Joseph TA 

PROVIDER: S-EPMC7325845 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature