Structure, Dynamics and Cellular Insight Into Novel Substrates of the <i>Legionella pneumophila</i> Type II Secretion System.

ABSTRACT: Legionella pneumophila is a Gram-negative bacterium that is able to replicate within a broad range of aquatic protozoan hosts. L. pneumophila is also an opportunistic human pathogen that can infect macrophages and epithelia in the lung and lead to Legionnaires' disease. The type II secretion system is a key virulence factor of L. pneumophila and is used to promote bacterial growth at low temperatures, regulate biofilm formation, modulate host responses to infection, facilitate bacterial penetration of mucin gels and is necessary for intracellular growth during the initial stages of infection. The L. pneumophila type II secretion system exports at least 25 substrates out of the bacterium and several of these, including NttA to NttG, contain unique amino acid sequ

SUBMITTER: Portlock TJ 

PROVIDER: S-EPMC7325957 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature