Regulatory Nucleotide Sequence Signals for Expression of the Genes Encoding Ribosomal Proteins.

ABSTRACT: Ribosomal proteins (RPs) are essential components that translate genetic information from mRNA templates into proteins. Their expressional dysregulation adversely affects the survival and growth of human cells. Nevertheless, little is known about the nucleotide sequences regulating the expression of RPs. Genome-wide associations for expression level of 70 RP genes were conducted across expression stages. Eighteen expression regulatory quantitative trait loci (erQTLs) were identified for protein abundances of 21 RPs (P < 1 × 10^-5), but not for their mRNA expression and ribosome occupancy (P > 1 × 10^-5). These erQTLs for protein abundance (pQTLs) were all trans-acting. Three of the pQTLs were associated with the expression of long noncoding RNAs (ln

SUBMITTER: Ryu J 

PROVIDER: S-EPMC7326009 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature