Paracrine effects of intraocularly implanted cells on degenerating retinas in mice.

ABSTRACT:

Background

Retinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and stress-associated aging. In addition to gene therapies for known genetically defective retinal degeneration, cellular therapies have been widely explored for restoring vision in both preclinical animal models and clinical trials. Stem cells of distinct tissue sources and their derived lineages have been tested for treating retinal degeneration; most of them were reported to be effective to some extent in restoring/improving deteriorated vision. Whether this visual improvement is due to a functional integration of grafted cells to substitute for lost retinal neurons in recipients or due to their neuroprotective and neurotrophic effects to retain reci

SUBMITTER: Liu X 

PROVIDER: S-EPMC7326149 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature