Tensile force-induced cytoskeletal remodeling: Mechanics before chemistry.

ABSTRACT: Understanding cellular remodeling in response to mechanical stimuli is a critical step in elucidating mechanical activation of biochemical signaling pathways. Experimental evidence indicates that external stress-induced subcellular adaptation is accomplished through dynamic cytoskeletal reorganization. To study the interactions between subcellular structures involved in transducing mechanical signals, we combined experimental data and computational simulations to evaluate real-time mechanical adaptation of the actin cytoskeletal network. Actin cytoskeleton was imaged at the same time as an external tensile force was applied to live vascular smooth muscle cells using a fibronectin-functionalized atomic force microscope probe. Moreover, we performed computational simulations of active cytosk

SUBMITTER: Li X 

PROVIDER: S-EPMC7326277 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature