Dose-Response Study on Surfactant Nebulization Therapy During Nasal Continuous Positive Airway Pressure Ventilation in Spontaneously Breathing Surfactant-Deficient Newborn Piglets.

ABSTRACT:

Objectives

The current clinical treatment of neonates with respiratory distress syndrome includes endotracheal intubation and intratracheal instillation of exogenous surfactant. Nebulization of surfactant offers an attractive alternative. The aims of this study were to test nebulization as a noninvasive method of administering surfactant and determine the optimal dose for the treatment of respiratory distress syndrome-associated pathophysiology of the neonatal lungs.

Design

Prospective, randomized, animal model study.

Setting

An experimental laboratory.

Subjects

Thirty-six newborn piglets.

Interventions

Different doses (100, 200, 400, and 600 mg/kg) of poractant alfa were administered via a vibrating membrane nebulizer (eFlow-Neos; Pari Pharma GmbH, Star

SUBMITTER: Rey-Santano C 

PROVIDER: S-EPMC7326365 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature