Genes Regulated by HPV 16 E6 and High Expression of NFX1-123 in Cervical Cancers.

ABSTRACT:

Purpose

High-risk human papillomaviruses (HR HPV) cause cervical cancer, and in these cancers, HPV type 16 is the most common HR type. The HR viral oncogenes E6 and E7 partner with cellular proteins to drive cancer and modulate immune pathways; previously, we demonstrated in keratinocytes that HPV 16 E6 and high expression of the endogenous host protein partner NFX1-123 led to the increased expression of multiple genes, including Notch1, secretory leukocyte peptidase inhibitor (SLPI), and retinoic acid early transcript 1G (RAET1G). The present study was conducted to determine if NFX1-123 was highly expressed in cervical cancer and if genes increased by NFX1-123 and 16E6 in keratinocytes were also increased in cervical cancers.

Materials and methods

The Cancer Genome Atlas (T

SUBMITTER: Chintala S 

PROVIDER: S-EPMC7326398 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature