Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study.

ABSTRACT:

Background

An important feature of severe acute respiratory syndrome coronavirus 2 pathogenesis is COVID-19-associated coagulopathy, characterised by increased thrombotic and microvascular complications. Previous studies have suggested a role for endothelial cell injury in COVID-19-associated coagulopathy. To determine whether endotheliopathy is involved in COVID-19-associated coagulopathy pathogenesis, we assessed markers of endothelial cell and platelet activation in critically and non-critically ill patients admitted to the hospital with COVID-19.

Methods

In this single-centre cross-sectional study, hospitalised adult (≥18 years) patients with laboratory-confirmed COVID-19 were identified in the medical intensive care unit (ICU) or a specialised non-ICU COVID-19 floor in

SUBMITTER: Goshua G 

PROVIDER: S-EPMC7326446 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature