Tolvaptan Versus Fluid Restriction in the Treatment of Hyponatremia Resulting from SIADH Following Pituitary Surgery.

ABSTRACT:

Context

The relevance of hyponatremia has been acknowledged by guidelines from the United States (2013) and Europe (2014). However, treatment recommendations differ due to limited evidence.

Objective

In hyponatremia following pituitary surgery-caused by the syndrome of inappropriate antidiuretic hormone (SIADH) secretion-we compared fluid restriction with the pharmacological increase of water excretion by blocking the vasopressin 2 receptors with tolvaptan at a low and a moderate dose.

Design

Prospective observational study.

Setting

Neurosurgical Department of a University hospital with more than 200 surgical pituitary procedures per year.

Patients

Patients undergoing pituitary surgery and developing serum sodium below 136 mmol/L. The diagnosis of SIADH

SUBMITTER: Kleindienst A 

PROVIDER: S-EPMC7326480 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature