Targeted surveillance strategies for efficient detection of novel antibiotic resistance variants.

ABSTRACT: Genotype-based diagnostics for antibiotic resistance represent a promising alternative to empiric therapy, reducing inappropriate antibiotic use. However, because such assays infer resistance based on known genetic markers, their utility will wane with the emergence of novel resistance. Maintenance of these diagnostics will therefore require surveillance to ensure early detection of novel resistance variants, but efficient strategies to do so remain undefined. We evaluate the efficiency of targeted sampling approaches informed by patient and pathogen characteristics in detecting antibiotic resistance and diagnostic escape variants in Neisseria gonorrhoeae, a pathogen associated with a high burden of disease and antibiotic resistance and the development of genotype-based diagnostics.

SUBMITTER: Hicks AL 

PROVIDER: S-EPMC7326491 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature