Human milk oligosaccharides and their association with late-onset neonatal sepsis in Peruvian very-low-birth-weight infants.

ABSTRACT:

Background

Oligosaccharides are the third most abundant component in human milk. They are a potential protective agent against neonatal sepsis.

Objectives

We aimed to explore the association between human milk oligosaccharides (HMOs) and late-onset sepsis in very-low-birth-weight infants, and to describe the composition and characteristics of HMOs in Peruvian mothers of these infants.

Methods

This is a secondary data analysis of a randomized clinical trial. We conducted a retrospective cohort study of mothers and their very-low-birth-weight (<1500 g) infants with ≥1 milk sample and follow-up data for >30 d. HMOs were measured by high performance liquid chromatography (HPLC). We used factor analysis and the Mantel-Cox test to explore the association between HMOs and la

SUBMITTER: Torres Roldan VD 

PROVIDER: S-EPMC7326596 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature