Quantification of ¹¹C-PIB kinetics in cardiac amyloidosis.

ABSTRACT:

Background

The purpose of this work was to determine the optimal tracer kinetic model of ¹¹C-PIB and to validate the use of the simplified methods retention index (RI) and standardized uptake value (SUV) for quantification of cardiac ¹¹C-PIB uptake in amyloidosis.

Methods and results

Single-tissue, reversible and irreversible two-tissue models were fitted to data from seven cardiac amyloidosis patients who underwent ¹¹C-PIB PET scans and arterial blood sampling for measurement of blood radioactivity and metabolites. The irreversible two-tissue model (2Tirr) best described cardiac ¹¹C-PIB uptake. RI and SUV showed high correlation with the rate of irreversible binding (K_i) from the 2Tirr model (r²=0.95 and r

SUBMITTER: Kero T 

PROVIDER: S-EPMC7326793 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature