Progress in Liver Transplant Tolerance and Tolerance-Inducing Cellular Therapies.

ABSTRACT: Liver transplantation is currently the most effective method for treating end-stage liver disease. However, recipients still need long-term immunosuppressive drug treatment to control allogeneic immune rejection, which may cause various complications and affect the long-term survival of the recipient. Many liver transplant researchers constantly pursue the induction of immune tolerance in liver transplant recipients, immunosuppression withdrawal, and the maintenance of good and stable graft function. Although allogeneic liver transplantation is more tolerated than transplantation of other solid organs, and it shows a certain incidence of spontaneous tolerance, there is still great risk for general recipients. With the gradual progress in our understanding of immune regulatory mechanisms, a

SUBMITTER: Du X 

PROVIDER: S-EPMC7326808 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature