Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe₃O₄@Al(OH)₃ nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution.

ABSTRACT:

Background

Mesenchymal stem cells (MSCs) have shown potential for treatment of different diseases. However, their working mechanism is still unknown. To elucidate this, the non-invasive and longitudinal tracking of MSCs would be beneficial. Both iron oxide-based nanoparticles (Fe₃O₄ NPs) for magnetic resonance imaging (MRI) and radiotracers for positron emission tomography (PET) have shown potential as in vivo cell imaging agents. However, they are limited by their negative contrast and lack of spatial information as well as short half-life, respectively. In this proof-of-principle study, we evaluated the potential of Fe₃O₄@Al(OH)₃ NPs as dual PET/MRI contrast agents, as they allow stable binding of [¹⁸F]F^-

SUBMITTER: Belderbos S 

PROVIDER: S-EPMC7326875 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature