Human Cardiac Mesenchymal Stromal Cells From Right and Left Ventricles Display Differences in Number, Function, and Transcriptomic Profile.

ABSTRACT:

Background

Left ventricle (LV) and right ventricle (RV) are characterized by well-known physiological differences, mainly related to their different embryological origin, hemodynamic environment, function, structure, and cellular composition. Nevertheless, scarce information is available about cellular peculiarities between left and right ventricular chambers in physiological and pathological contexts. Cardiac mesenchymal stromal cells (C-MSC) are key cells affecting many functions of the heart. Differential features that distinguish LV from RV C-MSC are still underappreciated.

Aim

To analyze the physiological differential amount, function, and transcriptome of human C-MSC in LV versus (vs.) RV.

Methods

Human cardiac specimens of LV and RV from healthy donors were use

SUBMITTER: Stadiotti I 

PROVIDER: S-EPMC7327120 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature