Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP⁵⁺, prevents its acute hypotensive response.

ABSTRACT: Scavenging superoxide (O₂^•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transitioned to clinical trials, MnTnBuOE-2-PyP⁵⁺ (BuOE), a manganese porphyrin SOD mimic, is currently in clinical trials as a radioprotector for cancer patients; thus, providing hope for the use of SOD mimics in the clinical setting. However, BuOE transiently alters cardiovascular function including a significant and precipitous decrease in blood pressure. To limit BuOE's acute hypotensive action, we developed a mesoporous silica nanoparticle and lipid bilayer nanoformulation of BuOE (nanoBuO

SUBMITTER: Schlichte SL 

PROVIDER: S-EPMC7327277 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature