Assessing the genetic relationships between osteoarthritis and human plasma proteins: a large scale genetic correlation scan.

ABSTRACT:

Background

Osteoarthritis (OA) is a multifactorial complex disease. The impact of plasma proteins on OA remains elusive now.

Methods

The UK Biobank genome-wide association study data of OA was used here. Genome-wide SNP genotyping was performed using the Affymetrix UK BiLEVE Axiom or UK Biobank Axiom array. Equally, the GWAS summary data of 3,622 plasma proteins was derived from a recently published study. Consequently, linkage disequilibrium score regression (LD score regression) analysis was performed to evaluate the genetic correlation between each plasma protein and different sites of OA.

Results

Several suggestive plasma proteins were identified for OA. For hand OA, evidence of genetic correlation was observed for inter-alpha-trypsin inhibitor heavy chain H1 (coe

SUBMITTER: Liu L 

PROVIDER: S-EPMC7327363 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature