A quantitative evaluation of sciatic nerve stiffness after compression by shear wave elastography in diabetic rats.

ABSTRACT:

Background

Our study investigates the feasibility of using quantitative evaluation for nerve entrapment visualization by shear wave elastography (SWE) in diabetic rats.

Methods

A total of 24 male Sprague-Dawley (SD) rats were included in this study. Before injection of streptozotocin (STZ), the experimental groups were assigned as the diabetic nerve compression (DNC) group (DNC, n=18) and the control group (CON, n=6). The DNC model was created by wrapping a silicone tube around the nerve, and then the DNC group was divided into the DNC 2-week (DNC2W, n=6), 4-week (DNC4W, n=6), and 8-week (DNC8W, n=6) groups according to the different duration time of sciatic nerve compression. The nerve stiffness was detected by SWE. Meanwhile, motor nerve conduction velocity (MNCV) was dete

SUBMITTER: Li D 

PROVIDER: S-EPMC7327375 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature