C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes.

ABSTRACT: The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such as neurodegenerative diseases, inflammation, and cancer. Efforts to develop JNK-specific inhibitors have been ongoing for several decades. In this process, the structures of JNK in complex with various inhibitors have contributed greatly to the design of novel compounds and to the elucidation of structure-activity relationships. Almost 100 JNK structures with various compounds have been determined. Here we summarize the information gained from these structures and classify the inhibitors into several groups based on the binding mode. These groups include inh

SUBMITTER: Duong MTH 

PROVIDER: S-EPMC7327381 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature