Hypertensive coronary microvascular dysfunction: a subclinical marker of end organ damage and heart failure.

ABSTRACT:

Aims

Hypertension is a well-established heart failure (HF) risk factor, especially in the context of adverse left ventricular (LV) remodelling. We aimed to use myocardial flow reserve (MFR) and global longitudinal strain (GLS), markers of subclinical microvascular and myocardial dysfunction, to refine hypertensive HF risk assessment.

Methods and results

Consecutive patients undergoing symptom-prompted stress cardiac positron emission tomography (PET)-computed tomography and transthoracic echocardiogram within 90 days without reduced left ventricular ejection fraction (<40%) or flow-limiting coronary artery disease (summed stress score ≥ 3) were included. Global MFR was quantified by PET, and echocardiograms were retrospectively analysed for cardiac structure and function. Pa

SUBMITTER: Zhou W 

PROVIDER: S-EPMC7327534 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature