Gender differences in molecular-guided therapy recommendations for metastatic malignant mesothelioma.

ABSTRACT:

Background

Malignant mesothelioma is an aggressive cancer and has a poor prognosis. Here, we analyzed the feasibility, molecular and gender aspects of targeted therapy recommendations for malignant mesothelioma based on the individual molecular tumor profile.

Methods

In this single-center, real-world retrospective analysis of our platform for precision medicine, we evaluated the molecular profiling of malignant mesothelioma in 14 patients, including nine men and five women. Tumor samples of the patients were examined with a 50 gene next-generation sequencing (NGS) panel, immunohistochemistry, and fluorescence in situ hybridization, to detect possible molecular aberrations which may be targeted by off-label therapy custom-tailored to the individual patient.

Results

In

SUBMITTER: Taghizadeh H 

PROVIDER: S-EPMC7327667 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature