Evaluating the Four Kallikrein Panel of the 4Kscore for Prediction of High-grade Prostate Cancer in Men in the Canary Prostate Active Surveillance Study.

ABSTRACT:

Background

Diagnosis of Gleason 6 prostate cancer can leave uncertainty about the presence of undetected aggressive disease.

Objective

To evaluate the utility of a four kallikrein (4K) panel in predicting the presence of high-grade cancer in men on active surveillance.

Design, setting, and participants

Plasma collected before the first and subsequent surveillance biopsies was assessed for 718 men prospectively enrolled in the multi-institutional Canary PASS trial. Biopsy data were split 2:1 into training and test sets. We developed statistical models that included clinical information and either the 4Kpanel or serum prostate-specific antigen (PSA).

Outcome measurements and statistical analysis

The endpoint was reclassification to Gleason ≥7. We used receiver op

SUBMITTER: Lin DW 

PROVIDER: S-EPMC7327706 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature