Structural MRI outcomes and predictors of disease progression in amyotrophic lateral sclerosis.

ABSTRACT:

Background and aims

Considering the great heterogeneity of amyotrophic lateral sclerosis (ALS), the identification of accurate prognostic predictors is fundamental for both the clinical practice and the design of treatment trials. This study aimed to explore the progression of clinical and structural brain changes in patients with ALS, and to assess magnetic resonance imaging (MRI) measures of brain damage as predictors of subsequent functional decline.

Methods

50 ALS patients underwent clinical evaluations and 3 T MRI scans at regular intervals for a maximum of 2 years (total MRI scans = 164). MRI measures of cortical thickness, as well as diffusion tensor (DT) metrics of microstructural damage along white matter (WM) tracts were obtained. Voxel-wise regression models and l

SUBMITTER: Spinelli EG 

PROVIDER: S-EPMC7327879 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature