NOD2 Influences Trajectories of Intestinal Microbiota Recovery After Antibiotic Perturbation.

ABSTRACT:

Background & aims

Loss-of-function variants in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) impair the recognition of the bacterial cell wall component muramyl-dipeptide and are associated with an increased risk for developing Crohn's disease. Likewise, exposure to antibiotics increases the individual risk for developing inflammatory bowel disease. Here, we studied the long-term impact of NOD2 on the ability of the gut bacterial and fungal microbiota to recover after antibiotic treatment.

Methods

Two cohorts of 20-week-old and 52-week-old wild-type (WT) C57BL/6J and NOD2 knockout (Nod2-KO) mice were treated with broad-spectrum antibiotics and fecal samples were collected to investigate temporal dynamics of the intestinal microbiota (bacteria and fung

SUBMITTER: Moltzau Anderson J 

PROVIDER: S-EPMC7327897 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature