Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response.

ABSTRACT:

Background

Human dermal fibroblasts (HDF) can be used as a cellular model relatively easily and without genetic engineering. Therefore, HDF represent an interesting tool to study several human diseases including psychiatric disorders. Despite major depressive disorder (MDD) being the second cause of disability in the world, the efficacy of antidepressant drug (AD) treatment is not sufficient and the underlying mechanisms of MDD and the mechanisms of action of AD are poorly understood.

Objective

The aim of this review is to highlight the potential of HDF in the study of cellular mechanisms involved in MDD pathophysiology and in the action of AD response.

Methods

The first part is a systematic review following PRISMA guidelines on the use of HDF in MDD research. The sec

SUBMITTER: Mesdom P 

PROVIDER: S-EPMC7327943 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature