Environmental risk factors and their footprints in vivo - A proposal for the classification of oxidative stress biomarkers.

ABSTRACT: Environmental agents, including socioeconomic condition, and host factors can act as causal agents and risk factors in disease. We use biomarkers and sociomarkers to study causal factors, such as overproduction of reactive oxygen species (ROS) which could play a role in disease through oxidative stress. It is therefore important to define the exact meaning of the biomarker we measure. In this review we attempt a classification of biomarkers related to oxidative stress based on their biological meaning. We define as type zero biomarkers the direct measurement of ROS in vivo in patients. Type 1 biomarkers are the most frequently used indicators of oxidative stress, represented by oxidized lipids, proteins or nucleic acids and their bases. Type 2 biomarkers are indicators of the activation of

SUBMITTER: Ghezzi P 

PROVIDER: S-EPMC7327955 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature