Oxidative stress pathways of air pollution mediated toxicity: Recent insights.

ABSTRACT: Ambient air pollution is a leading environmental cause of morbidity and mortality globally with most of the outcomes of cardiovascular origin. While numerous mechanisms are proposed to explain the link between air pollutants and cardiovascular events, the evidence supports a role for oxidative stress as a critical intermediary pathway in the transduction of systemic responses in the cardiovascular system. Indeed, alterations in vascular function are a critical step in the development of cardiometabolic disorders such as hypertension, diabetes, and atherosclerosis. This review will provide an overview of the impact of particulate and gaseous pollutants on oxidative stress from human and animal studies published in the last five years. We discuss current gaps in knowledge and evidence to dat

SUBMITTER: Gangwar RS 

PROVIDER: S-EPMC7327965 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature