Identification of Differentially Expressed Hematopoiesis-associated Genes in Term Low Birth Weight Newborns by Systems Genomics Approach.

ABSTRACT:

Background

Low Birth Weight (LBW) (birth weight <2.5 Kg) newborns are associated with a high risk of infection, morbidity and mortality during their perinatal period. Compromised innate immune responses and inefficient hematopoietic differentiation in term LBW newborns led us to evaluate the gene expression status of hematopoiesis.

Materials and methods

In this study, we compared our microarray datasets of LBW-Normal Birth Weight (NBW) newborns with two reference datasets to identify hematopoietic stem cells genes, and their differential expression in the LBW newborns, by hierarchical clustering algorithm using gplots and RcolorBrewer package in R.

Results

Comparative analysis revealed 108 differentially expressed hematopoiesis genes (DEHGs), of which 79 genes were up

SUBMITTER: Singh S 

PROVIDER: S-EPMC7327969 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature