NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy.

ABSTRACT: Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure, and the underlying mechanism remains largely elusive. Here we investigated whether NLRP3 inflammasome-mediated pyroptosis contributes to non-ischemic DCM and dissected the underlying mechanism. We found that hyper activated NLRP3 inflammasome with pyroptotic cell death of cardiomyocytes were presented in the myocardial tissues of DCM patients, which were negatively correlated with cardiac function. Doxorubicin (Dox)-induced DCM characterization disclosed that NLRP3 inflammasome activation and pyroptosis occurred in Dox-treated heart tissues, but were very marginal in either NLRP3^-/- or caspase-1^-/- mice. Mechanistically, Dox enhanced expressions of NOX1 and NOX4 and induced mitochondrial f

SUBMITTER: Zeng C 

PROVIDER: S-EPMC7327979 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature