Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO.

ABSTRACT: Cardiovascular disease is the leading cause of death and disability worldwide with increased oxidative stress and reduced NO bioavailability serving as key risk factors. For decades, elevation in protein abundance and enzymatic activity of xanthine oxidoreductase (XOR) under hypoxic/inflammatory conditions has been associated with organ damage and vascular dysfunction. Recent reports have challenged this dogma by identifying a beneficial function for XOR, under similar hypoxic/acidic conditions, whereby XOR catalyzes the reduction of nitrite (NO2^-) to nitric oxide (NO) through poorly defined mechanisms. We previously reported that hydrogen sulfide (H₂S/sulfide) confers significant vascular benefit under these same conditions via NO2^- mediated mechanisms ind

SUBMITTER: Pardue S 

PROVIDER: S-EPMC7327988 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature