In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer.

ABSTRACT: Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial role in sustaining the growth and survival of cancer cells. A central function of mitochondria is the synthesis of ATP by oxidative phosphorylation, known as mitochondrial bioenergetics. Mitochondria maintain oxidative phosphorylation by creating a membrane potential gradient that is generated by the electron transport chain to drive the synthesis of ATP¹. Mitochondria are essential for tumour initiation and maintaining tumour cell growth in cell culture and xenografts^2,3. However, our understanding of oxidative mitochondrial metabolism in cancer is limited because most studies have been performed in vitro in cell culture models. This highlights a need for in vivo studies to be

SUBMITTER: Momcilovic M 

PROVIDER: S-EPMC7328016 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature