Stable mitochondrial CICIII₂ supercomplex interactions in reptiles versus homeothermic vertebrates.

ABSTRACT: The association of complex I (CI), complex III (CIII) and complex IV (CIV) of the mitochondrial electron transport chain into stable high molecular weight supercomplexes (SCs) has been observed in several prokaryotes and eukaryotes, but among vertebrates it has only been examined in mammals. The biological role of these SCs is unclear but suggestions so far include enhanced electron transfer between complexes, decreased production of the reactive oxygen species (ROS) O₂^- and H₂O₂, or enhanced structural stability. Here, we provide the first overview on the stability, composition and activity of mitochondrial SCs in representative species of several vertebrate classes to determine patterns of SC variation across endotherms and ectotherms. We found

SUBMITTER: Bundgaard A 

PROVIDER: S-EPMC7328143 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature